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Chorionic biopsy is a diagnostic method that involves obtaining a small amount of the placenta. The chorion is the outer membrane surrounding the embryo and contributes to the formation of the placenta. The test is to enable cytogenetic and molecular studies of the foetus to observe possible chromosomal alterations. In the biopsy, a needle is introduced through the abdominal wall or through a catheter that filters through the cervix, under continuous ultrasonic control. Chorionic biopsy should be performed on women who are 12 weeks into their pregnancy and are over 35 years of age (this is considered advanced maternal age), when there has been a change in the number of chromosomes in the embryo, and in pregnant women who have a personal and/or family history of chromosomal abnormalities.